No, the antibiotic Zithromax does not contain fluoride. The main active ingredient in Zithromax tablets is azithromycin, and the main inactive ingredients are the following: titanium dioxide, hypromellose, triacetin, and lactose, which make up the coating, as well as pregelatinized starch, magnesium stearate, sodium lauryl sulfate, dibasic calcium phosphate anhydrous, and sodium croscarmellose.